Publications

Latest Publications

– BY DR. LEE

  • Lee LY, Zhou X, Patel SR, Polce DR, Isom OW, Crystal RG, Rosengart TK. Prolonged transgene expression in the rat myocardium mediated by an adeno-associated viral vector: implications for chronic cardiac therapy. Surgical Forum; 49:215-6, 1998.
  • Patel SR, Lee LY, Schwarz EA, Hahn RT, Jones E, Devereux RB, Kovesdi I, Hackett N, Isom OW, Crystal RG, Rosengart TK. Adenovirus-mediated angiogenic therapy produces minimal inflammation and no functional compromise following direct myocardial injection: implications for clinical use. Surgical Forum; 49:221-3, 1998.
  • Rosengart TK, Patel SR, Lee LY, Sanborn TA, Hachomovitch R, Kligfield PD, Hahn RT, Isom OW, Crystal RG. Safety of direct myocardial VEGF121 cDNA adenovirus-mediated angiogenesis gene therapy in conjunction with coronary bypass surgery. Circulation (suppl 17): I-319, 1998.
  • Lee LY and Rosengart TK. Transmyocardial laser revascularization and angiogenesis: the potential for therapeutic benefit. Sem Thor Cardiov Surg; 11(1):29-35, January 1999.
  • Lee LY, Zhou X, Polce DR, El-Sawy T, Patel SR, Thakker GD, Narumi K, Crystal RG, Rosengart TK, (Lee and Zhou, co-1st authors). Exogenous control of cardiac gene therapy: evidence of regulated myocardial transgene expression after adenoviral transfer of expression cassettes containing corticosteroid response element promoters. J Thor Cardiov Surg; 118:26-3, 1999.
  • Patel SR, Lee LY, Mack CA, Polce DR, El-Sawy T, Hackett NR, Ilercil A, Jones EC, Hahn RT, Isom OW, Rosengart TK, Crystal RG, (Patel and Lee, co-1st authors). Safety of direct myocardial administration of an adenovirus vector coding for vascular endothelial growth factor 121. Hum Gene Ther; 10:1331-1348, 1999.
  • Rosengart TK, Lee LY, Patel SR, Szulc M, Kligfield PD, Okin PM, Hackett NR, Isom OW, Crystal RG. Six month assessment of a phase I trial of angiogenic gene therapy for the treatment of coronary artery disease using direct intramyocardial administration of an adenovirus vector expressing the VEGF121 cDNA. Ann Surg; 230(4):466-72, 1999.
  • Rosengart TK, Lee LY, Patel SR, Sanborn TA, Parikh M, Bergman GW, Hachamovitch R, Szulc M, Kligfield PD, Okin PM, Hahn RT, Devereux RB, Post MR, Hackett NR, Foster T, Grasso TM, Lesser ML, Isom OW, Crystal RG. Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of anadenovirus vector expressing the VEGF121 cDNA to individuals with clinically significant severe coronary artery disease. Circ; 100(5): 468-474, 1999.
  • Hamawy AH, Lee LY, Crystal RG, Rosengart TK. Cardiac angiogenesis and gene therapy: a strategy for myocardial revascularization. Curr Opin Cardiol; 14:515-522, 1999.
  • Sanborn TA, Terrazona N, Deutsch E, Lee LY, Hackett N, El-Sawy T, Crystal RG, Rosengart TK. Percutaneous endocardial gene therapy: in vivo gene transfer and expression. J Am Coll Cardiol; 116:763-9, 1999.
  • Rosengart TK, Lee LY, Port JL, Crystal RG. Video assisted epicardial delivery of angiogenic gene therapy to the human myocardium utilizing an adenovirus vector encoding for VEFG121.J Am Coll Cardiol; 33:384A, 1999.
  • Lee LY, Polce DR, El-Sawy T, Hackett NR, Isom OW, Crystal RG, Rosengart TK. Adenovirus coding for VEGF121 induces angiogenesis despite the presence of anti-Ad neutralizing antibodies in the immunized host. Circulation; 100 (Suppl 1): I-312, 1999..
  • Rosengart TK, Lee LY, Port JL, Hahn RT, Devereux RB, Finnin E, Isom OW, Crystal RG. Video assisted epicardial delivery of angiogenic gene therapy to the human myocardium utilizing an adenovirus vector encoding for VEGF121. Circulation; 100 (Suppl 1): I- 312, 1999.
  • Lee LY, Patel SR, Hackett NR, Mack CA, Polce DR, El-Sawy T, Hachamovitch R, Zanzonico P, Sanborn TA, Parikh M, Isom OW, Crystal RG, Rosengart TK. Focal angiogen therapy using intramyocardial delivery of an adenovirus vector coding for vascular endothelial growth factor 121. Ann Thor Surg; 69:14-24, 2000.
  • Lee LY, O’Hara M, Finnin E, Hachamovitch R, Szulc M, Kligfield PD, Okin PM, Isom OW, and Rosengart TK. Transmyocardial laser revascularization with the excimer laser: results of stress analyses at one year follow-up. Ann Thor Surg; 70(2):498-503, 2000.
  • Lee LY, Rahman GF, Zhou X, Polce DR, Yin X, Hackett NR, Isom OW, Crystal GR, Rosengart TK. Long term (>1 year) high level myocardial transgene expression with an adeno-associated virus. J Am Coll Cardiol; 35 (Suppl): 278, 2000.
  • Lee LY, Rahman GF, Lee KT, El-Sawy T, Hackett NR, Isom OW, Crystal RG, Rosengart TK. Global perfusion vs regional administration strategies for myocardial gene therapy. J Amer Coll Cardio (Suppl); 35: 279, 2000.
  • Deutsch E, Tarazona N, Sanbon TA, Martin JL, Lee LY, Hackett N, El-Sawy T, Blanco I, Fromkin KR, Rosengart TK, Crystal RG. Percutaneous endocardial gene therapy: patterns of in vivo gene expression related to regional myocardial delivery. J. Amer Coll Cardio (Suppl); 35: 6, 2000.
  • Sanborn TA, Hackett NR, Lee LY, Blanco I, Tarazona N, Deutsch E, Rosengart TK, Crystal RG. Regional intramyocardial vascular endothelial growth factor (VEGF) gene transfer and expression using a fluoroscopically guided catheter-based technique. J Amer Coll Cardio (Suppl); 35: 74, 2000.
  • Samy SJ, Hamawy AH, Lee LY, Polce DR, Isom OW, Crystal RG, Rosengart TK, Administration of an adenovirus vector coding for the vascular endothelial growth factor 121 in the non-ischemic state protects distal hindlimb perfusion following vascular occlusion. Mol Ther; 1: S201, 2000.
  • Hackett NR, Lee LY, Silva I, O’Leary J, Rosengart TK, Crystal RG. Use of quantitative TaqMan Real-Time PCR to track the time-dependent distribution of gene transfer vectors in vivo. Molec Therap; 2(6):649-656, 2000.
  • Hamaway A, Samy SA, Lee LY, Polce DR, Isom OW, Crystal RG, Rosengart TK. Transmyocardial revascularization and administration of adenovirus encoding for VEGF 121 act synergistically to increase survival in an experimental animal model of severe myocardial ischemia. Surgical Forum; 51:110-111, 2000.
  • Hamaway AH, Samy SA, Lee LY, Rosen C, Sanborn TA, Isom OW, Crystal RG, Rosengart TK. Coadministration of adenovirus encoding for VEGF121 and transmycardial revascularization with an excimer laser increase survival in a double ameroid model of severe myocardial ischemia. Circulation; suppl 2000.
  • Hamaway A, Lee LY, Samy SA, Polce DR, Woo CS, Sculz M, Vasquez M, Rosengart TK. Transmyocardial laser revascularization dose response: enhanced perfusion in a porcine ischemia model as a function of channel density. Ann Thor Surg; 72(3):817-22, Sept 2001.
  • Sanborn TA, Hackett NR, Lee LY, El-Sawy T, Blanco I, Terrazona N, Deutsch E, Crystal RG, Rosengart TK. Percutaneous endocardial transfer and expression of genes to the myocardium utilizing fluoroscopic guidance. Catheter Cardiovascular Intervention; 52(2):260-6, 2001.
  • Lee LY, DeBois WJ, Krieger KH, Girardi LN, McVey J, Russo L, Ko W, Altorki NK, Brodman RA, Isom OW. The effects of platelet inhibitors on blood use in cardiac surgery. Perf; 17(1):33-7, Jan 2002.
  • Girardi LN, Krieger KH, Altorki NK, Mack CA, Lee LY, Isom OW. Ruptured descending and thoracoabdominal aortic aneurysms. Ann Thor Surg.; 74:1066-1070, 2002.
  • DeBois WJ, Liu J, Lee LY, Girardi LN, Mack C, Tortolani A, Krieger KH, Isom OW. Diagnosis and treatment of heparin-induced thrombocytopenia. Perf; 18: 47-53, 2003.
  • DeBois WJ, Girardi LN, Lee LY, Mack C, Elmer B, McCusker K, Krieger KH, Isom OW. Negative fluid displacement: an alternative method to assess patency of arterial line cannulation. Perf; 18(1):67-70, March 2003.
  • Bacchetta M, Ko W, Girardi LN, Mack CA, Altorki NK, Krieger KH, Isom OW, Lee LY. Outcomes of cardiac surgery in nonagenarians: a 10-year experience. Ann Thorc Surg; 75:1215-1220, 2003.
  • Girardi LN, Krieger KH, Lee LY, Mack CA, Tortolani AJ, Isom OW. Management strategies for type A dissection complicated by peripheral vascular malperfusion. Ann Thorac Surg; 77:1309-14, 2004.
  • Girardi LN, Krieger KH, Mack CA, Lee LY, Tortolani AJ, Isom OW. Does cross-clamping the arch increase the risk of descending thoracic and thoracoabdominal aneurysm repair? Ann Thorac Surg.; 79:133-8, 2005.
  • DeBois WJ, Liu J, Lee LY, Girardi LN, Ko W, Krieger KH, Isom OW. Cardiopulmonary bypass in patients with pre-existing coagulopathy. JECT; 37:15-22, 2005.
  • Mack CA, Milla F, Girardi LN, Ko W, Lee LY, Tortolani AJ, Krieger KH, Isom OW. The surgical treatment of atrial fibrillation using argon-based cryoablation during concomitant cardiac procedures. Circulation; 112 (9 Suppl): I1-6, Aug 30, 2005.
  • Bacchetta MD, Girardi LN, Southard EJ, Mack CA, Ko W, Tortolani AJ, Krieger KH, Isom OW, Lee LY. Comparison of open versus bedside percutaneous dilatational tracheostomy in the cardiothoracic surgical patient. Outcomes and financial analysis. Annals of Thoracic Surgery; 79:1879-85, 2005.
  • Oribabor C, Mansuroglu N, Tinker A, Mariano A., Gebreab F, Bernstein L, Lee LY, Tortolani A.: Perioperative Use of Amiodarone in High Risk Cardiac Surgery Patients to Achieve Normal Sinus Rhythm Upon Discharge. Chest; 128(4): Suppl, 2005.
  • Oribabor C, Mansuroglu N, Khusid F, Patten A, Suleiman M, Primiano J, Lee LY, Tortolani A.: Low Extubation Times in Cardiac Surgery Patients Using The Rapid Shallow Breathing Index. Chest; 128(4):Suppl., 2005.
  • DeBois WJ, Liu J, Elmer B, Ebrahimi H, Voevidko L, Lee LY, Krieger KH, Isom OW, Girardi LN.: Heparin Sensitivity Test for Patients Requiring Cardiopulmonary Bypass. J Extra Corpor Technol; 38(4):307-9, Dec 2006.
  • Girardi LN, Krieger KH, Mack CA, Lee LY, Tortolani AJ, Isom OW.: Reoperations on the ascending aorta and aortic root in patients with previous cardiac surgery. Annals of Thoracic Surgery; 82:1407-12, 2006.
  • Girardi LN, Krieger KH, Mack CA, Lee LY, Tortolani AJ, Isom OW.: Correspondance; Reply. Annals of Thoracic Surgery; 81:790, 2006.
  • Milla F, Skubas N, Briggs WM, Girardi LN, Lee LY, Ko W, Tortolani AJ, Krieger KH, Isom OW, Mack CA.: Epicardial beating heart cryoablation using a novel argon-based cryoclamp and linear probe. J Thorac Cardiovasc Surg; 131(2):403-11, Feb 2006.
  • Skubas, N., Slepian RL, Lee LY., Tortolani A.: Tricuspid Regurgitation Caused byEustachian Valve Endocarditis. Anesth Analg.; 103 (6):1410-1411, Dec 2006.
  • Mansuroglu N, Ali M, Oribabor C, Matatov V, Bernstein L, Elzomor W, Tinker A, Nazares M, Koloyian D, Lee LY, Torolani A.: Serum Cortisol Level and Coronary Artery Bypass Surgery Patients, Chest; 130(4):188S, 2006.
  • Haq S, Alam M, Bernstein L, Banko L, Saul B, Lee LY, Sacchi T, Heitner J.: Anemia as an Independent Predictor of Elevated Pro-BNP Levels in Patients without Evidence of Heart Failure and Normal Renal Function, Circulation (supplement), 114 (11): 771-772, 2006.
  • Debois W, Liu J, Elmer B, Ebrahimi H, Voevidko L, Lee LY, Krieger K, Isom Ow, Girardi L.: Heparin Sensitivity Test For Patients RequiringCardiopulmonary Bypass. Journal Of The American Society Of Extra- Corporeal Technology; 38:307-309, 2007.
  • Amchentsev A, Ali M, Mansuroglu N, Oribabor C, Elzomor WM., Patten A, Heitner J, Gruenburg B, Tortolani AJ, Lee LY.: Vasopressors in Cardiac Surgery: The Role of the Adrenal Gland, Chest; 132(4):538c, 2007.
  • Bishay A, Raoof S, Esan A, Sung A, Wali S, Lee LY, George L, Saleh A, Baumann M.: Update on Pleural Diseases – 2007, Ann Thorac Med.; 2(3):128-42, Jul 2007.
  • Haq SA, Heitner JF, Lee LY, Kassotis JT.: Late Presentation of a Lead perforation as a Complication of Permanent pacemaker Insertion, Angiology; 59(5):619-21, Oct-Nov 2008.
  • Oribabor C, Khusid F, Fisher E, Mansuroglu N, Lee LY, Tortolani A.: Iloprost Improves Cardiac Hemodynamic Parameters of Pulmonary Artery Hypertension in Open Heart Surgery. Respiratory Care; 53(11), Nov 2008.
  • Oribabor C, Khusid F, Fisher E, Mansuroglu N, Lee LY, Tortolani A.: Low Extubation Times in Cardiac Surgery Patients: Integration of Respiratory Therapy Driven Protocols. Respiratory Care; 53(11), Nov 2008.
  • Tavakol M, Hassan KZ, Abdula RK, Briggs W, Oribabor CE, Tortolani AJ, Sacchi TJ, Lee LY, Heitner JF. Utility of brain natriuretic peptide as a predictor of atrial fibrillation after cardiac operations. Ann Thorac Surg; 88(3):802-7, Sep 2009.
  • Bacchetta MD, Salemi A, Milla F, Hong MK, Tio F, Zhou Y, Chen R, Southward E, Lee LY, Mack CA, Krieger KH, Isom OW, Ko W, Borer JS, Catanzaro DF. Low-dose spironolactone: effects on artery-to-artery vein grafts and percutaneous coronary intervention sites. Am J Ther.; 16(3)204-14, May-Jun 2009.
  • Praeger P, Praeger J, Lee LY: Off-Pump Plication of Left Ventricular Aneurysm. Ann Thorac Surg; 92 (4):1514-6, Oct 2011.
  • Abdel-Razek A, Lee LY, Tozzi R.: HCM in a young adult with RV aneurysm: report of a rare finding and review of the literature. Heart Views. Case Report, 12(3), 112-117, 2011.
  • Siegler JC, Rehman S, Bhumireddy GP, Abdula R, Klem I, Brener SJ, Lee LY, Dunbar CC, Saul B, Sacchi TJ, Heitner JF.: The Accuracy of the Electrocardiogram During Exercise Stress Test Based on Heart Size. PLoS One, 6(8):e23044, 2011.
  • Mokashi S, Rajab TK, Lee LY, McCain DA, Abdel-Razek A, Elmann E. Extracorporeal Membrane Oxygenation Support after Ivor-Lewis Esophagectomy for Esophageal Adenocarcinoma. Annals of Thoracic Surgery. 2014 March; 97(3): 1073-5.
  • Preeshagul I, Gharbaran R, Jeong KH, Abdel-Razek A, Lee LY, Elman E, Suh, KS. Potential Biomarkers for Predicting Outcomes in CABG Cardiothoracic Surgeries. Journal of Cardiothoracic Surgery. July 2013, 8:176.
  • Lemaire A, Anderson MB, Lee LY, Scholz P, Prendergast T, Goodman A, Lozano AM, Spotnitz A, Batsides G. The Impella Device for Acute Mechanical Circulatory Support in Patients in Cardiogenic Shock. The Annals of Thoracic Surgery, Volume 97, Issue 1, January 2014, Pages 133-138.
  • Lemaire A, Lee LY, Ghaly A, Spotnitz A, Solina A, Batsides G. The Impella Device as a Temporary Bridge for Acute Mechanical Circulatory Support. J of Clinical Case Reports, January 2014, Volume 4, Issue 3.
  • Lemaire A, Scholz P, Chiricolo A, Israel A, Lee LY. Mitral Valve Repair Surgery in a Patient with Sickle Cell Disease. The Journal of Hematology. February 2014. Volume 3(1), Pages 10-12.
  • Lemaire A, Batsides G, Ghaly A, Solina A, Dombrovsky V, Spotnitz A, Lee LY. The Impact of Gastrointestional Complications on Patients who Undergo Coronary Artery Bypass Grafting. Journal of Cardiovascular Diseases and Diagnosis. April 15, 2014. Volume 2(3).
  • Lemaire A, Behrend V, Batsides G, Ghaly A, Solina A, Spotnitz A, Lee LY. Refractory Hypertension leads to both Type A and B Aortic Disssections in a Single Patient. Accepted for Publication to the Journal of Cardiovascular Diseases and Diagnosis. April 2014. Volume 2(3), Page 155.
  • Qi Y, Liu J, Saadat S, Tian X, Han Y, Fong GH, Pandolfi PP, Lee LY, Li S. PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. Cell Death Differ. November 14, 2014; doi:10. 1038/cdd.2014.185.
  • Lemaire A, Dombrovskiy V, Batsides G, Scholz P, Solina A, Brownstone N, Spotnitz A, Lee, LY. The Effect of Clostridium Difficile Infection on Cardiac Surgery Outcomes. Surgical Infections. Volume 16, Number 1. 2015.
  • Liu J, Qi Y, Saadat S, Han Y, Hsu SC, Rahimi S, Lee LY, Graham AM, Li S. CREG1 interacts with Sec8 to promote Cardiomyogenic differentiation from embryonic stem cells. Circulation. 130:A12203. 2014.
  • Lemaire A, Batsides G, Altmann D, Ghaly A, Nishimura T, Volk L, Spotnitz A, Lee LY. Right-Sided Congestive Heart Failure Resulting from an Intracavitary Myocardial Lymphoma. Cardiothoracic Surgery Network Journal. July 21, 2015.
  • Lemaire A, Maniatis G, Vagaonescu T, Batsides G, Moreyra A, Lee LY. Mobile Thrombus in the Ascending Aorta Associated with Acute Myocardial Infarction. Accepted for publication in the Journal of Hematology. July 2015.
  • Saadat S, Schultheis M, Azzolini A, Romero J, Dombrovskiy V, Odroniec K, Scholz P, Ghaly A, Lemaire A, Batsides G, Lee LY. Femoral Cannulation for Minimally Invasive Cardiac Surgery. Perfusion. 2015. June 1 (epub).
  • Saadat S, Schultheis M, Romero J, Azzolini A, Odroniec K, Dombrovskiy V, Scholz P, Lemaire A, Batsides G, Lee LY. Delayed Sternal Closure in Cardiac Surgery. Journal of Clinical and Experimental Cardiology, Volume 6, Issue 6, June 30, 2015.
  • Zhang Z, Amorosa LF, Coyle SM, Macor MA, Lubitz SE, Carson JL, Birnbaum MJ, Lee LY, Haimovich B. Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes. J Immunol. 2015 Jul 31.
  • Rahimi, SA, Shah N, Labinskyy V, Lee LY. Left Subclavian Artery Resvascularization in Preparation for Coronary Artery Bypass Grafting. Cardiology, Nov 28 2015;133(3):191-4;PMID:26613584.
  • Lemaire A, Dombrovskiy V, Batsides G, Ghaly A, Nishimura T, Volk L, Spotnitz A, Lee LY. Patients with Infectious Endocarditis and Drug Dependence have Worse Clinical Outcomes after Valvular Surgery. Innovations. In press.
  • Lemaire A, Batsides G, Ghaly A, Nishimura T, Lee LY. Effect of Repeat Sternotomy on Cardiac Surgery Outcomes. Innovations. In press.
  • Schultheis M, Saadat S, Frenchu K, Kandari J, Romero J, Dombrovskiy V, Ghaly A, Lemiare A, Batsides G, Rahimi S, Lee LY. Carotid Stenosis in Cardiac Surgery – No difference in Postoperative Outcomes. The Thoracic and Cardiovascular Surgeon. In press.
  • Gensini S, Dombrovskiy V, Nagarsheth K, Rahimi SA, Lee LY. Comparative Outcomes of Hybrid Versus Open Repair for Aortic Arch Disease in the Medicare Population. Journal of Surgical Research. In press.
  • Liu J, Qi Y, Li S, Hsu SC, Saadat S, Hsu J, Rahimi S, Lee LY, Yan C, Tian X, Han Y. CREG1 interacts with Sec8 to promote cell-cell adhesion during cardiomyogenesis, Circulation Research 2016. In press.
  • Saadat S, Chhabra K, Dombrovskiy V, Lemaire A, Ghaly A, Batsides G, Lee LY. Effect of Body Mass Index (BMI) On Outcomes In Cardiac Valve Surgery. Cardiology. In press.
  • Araujo L, Jinwala F, Lee LY, Li S. CREG: structure and biological functions. Invited review BioMed Research International. In press.
  • Lemaire A, Lee M, Batsides G, Ghaly A, Lee LY. Minimally Invasive Reoperative Surgery is the Preferred Approach after Previous Sternotomy, Innovations. In press.
  • Zhang Z, Amorosa LA, Coyle SM, Macor MA, Birnbaum MJ, Lee LY, Haimovich B. Insulin-dependent regulation of mTORC2-Akt-FoxO suppresses TLR4 signaling in human leukocytes: Relevance to type 2 diabetes. Diabetes. Accepted for publication.
  • Liu J, Qi Y, Li S, Hsu SC, Saadat S, Hsu J, Rahimi S, Lee LY, Yan C, Tian X, Han Y. CREG1 interacts with Sec8 to promote cardiomyogenic differentiation and cell-cell adhesion. Stem Cells. Accepted for publication.
  • Lemaire A, Saadat S, Batsides G, Ghaly A, Lee LY. Outcomes of Tricuspid Valve Surgery: 5Year Experience of the Forgotten Valve. Innovations. Accepted for publication.
  • Lemaire A, Lee M, Batsides, Ghaly A, Lee LY. Minimally Invasive Valvular Surgery Offers Improved Outcomes for Patients with Previous Sternotomy. Innovations. Accepted for publication.
  • Saadat S, Araujo L, Chai L, Dombrovskiy V, Lemaire A, Ghaly A, Batsides G, Lee LY. Effect of Body Mass Index (BMI) On Outcomes in Cardiac Surgery, Innovations. Accepted for publication
  • Saadat S, Coyle S, Macor M, Nair MR, Haimovich B, Lee LY. Inflammatory Markers in Cardiac Surgery. Innovations. Accepted for publication
  • Lemaire A, Dombrovskiy V, Saadat S, Batsides G, Ghaly A, Spotnitz A, Lee LY. Patients With Infectious Endocarditis and Drug Dependence Have Worse Clinical Outcomes After Valvular Surgery. Surgical Infections. Accepted for publication.

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